Prostatic Artery Embolization Is A Safe and Effective Long-Term Solution for Symptomatic BPH and LUTS

This international, multicenter prospective study assessed the clinical outcomes of prostatic artery embolization (PAE) in patients with benign prostatic hyperplasia (BPH) presenting with lower urinary tract symptoms (LUTS) or acute urinary retention (AUR). 
The primary endpoint was the 12-month change in the International Prostate Symptom Score (IPSS) for those with LUTS and catheter independence for AUR patients. Secondary outcomes included changes in IPSS at 3 and 24 months, quality of life (QoL) scores, the Sexual Health Inventory for Men (SHIM) questionnaire, technical success rates, and adverse events.

A total of 478 patients underwent PAE, including 405 with bothersome LUTS and 73 with AUR, with an average age of 70 years. 
In patients treated for LUTS, the mean IPSS significantly decreased from 21.8 at baseline to 9.3, 10.6, and 11.2 at 3, 12, and 24 months, respectively (p < 0.001). QoL scores improved from 4.7 to 2.0, 2.1, and 2.3 over the same periods. SHIM scores remained stable. Among AUR patients, 65.8% achieved catheter independence by 3 months, maintaining this status at 24 months. Adverse events were reported in 11.5% of patients, with serious events in 2.1%.
These results highlight PAE as a safe, effective option for managing symptomatic BPH and LUTS, demonstrating sustained symptom relief and improved quality of life over two years.