GERD: Gastroesophageal reflux disease; NSAIDs: Non-steroidal anti-inflammatory drugs; OR: Odds ratio; PRR: Pooled risk ratio; No drug-drug interaction; sustained relief; Supported by Meal independent dosing

Meta-analysis of 92 controlled trials of NSAIDs reported pooled dyspepsia percents and PRR by three dyspepsia definitions: strict, loose, and loose-less-heartburn.¹

Terms synonymous with epigastric pain/discomfort; Loose: ‘Strict’ definition plus terms for heartburn, nausea, bloating,
anorexia and vomiting; Loose-less-heartburn: ‘Loose’ definition without heartburn terms.

Strict: Terms synonymous with epigastric pain/discomfort; Loose: ‘Strict’ definition plus terms for heartburn, nausea, bloating, anorexia and vomiting; Loose-less-heartburn: ‘Loose’ definition without heartburn terms.

NSAIDs usage is associated with:

Increase in dyspepsia risk (p<0.05) by 36%.^1
Using the ‘strict’ definition, based solely on epigastric pain-related symptoms

Increase in development of GERD by ~4 times, OR=4.23.²

Heartburn development in 68% of patients and significant increase in acute reflux symptoms, p<0.0001, alone or in combination with aspirin.²

Abbreviations ▼

GERD: Gastroesophageal reflux disease; NSAIDs: Non-steroidal anti-inflammatory drugs; OR: Odds ratio; PRR: Pooled risk ratio.

References ▼

1. Straus WL, Ofman JJ, MacLean C, et al. Do NSAIDs cause dyspepsia? A meta-analysis evaluating alternative dyspepsia definitions. Am J Gastroenterol. 2002;97(8):1951–1958. 2. Mungan Z, Pınarbaşı Şimşek B. Which drugs are risk factors for the development of gastroesophageal reflux disease? Turk J Gastroenterol. 2017;28(Suppl 1):S38–S43.

LMRC Code: GGI-CO-A1-AQS-300041558-APPEMC-H24-1510 DOI of 25/08/2024 & DOE of 30/11/2024

Disclaimer: For the use of a Registered Medical Practitioner, Hospital or Laboratory only.

The images are for illustrative representation only and do not depict actual medical products, procedures, or outcomes. Refer to official medical guidance and product information for accurate details.

All content including: text, images, audio, or other formats were created for medical educational purposes only. Offerings for continuing education are clearly identified and the appropriate target audience is identified. This communication is restricted for the use of HCPs and must not be shared in public domain. The opinions expressed in this video are solely the views of the speaker. The presentation may contain off label usage of drug(s) aimed at educational purpose only. Dr. Reddy’s Laboratories Ltd including but not limited its Affiliates strictly does not recommend any off label usage of its marketing products. Prior to treatment kindly refer to the latest prescribing information approved by the local authorities. No part of this content may be used, reproduced, transmitted or stored in any form without the written permission of Dr. Reddy’s.

For Further Product Information Please Click Here

Vono-Always on Duty

Vono, containing Vonoprazan molecule, is a Potassium Competitive Acid Blocker which helps in treatment of Refractory GERD, Erosive Esophagitis, H.Pylori, Gastric & Duodenal Ulcers

Know more

NSAIDs: Augmenting the Risk of Gastric Complications

GERD: Gastroesophageal reflux disease; NSAIDs: Non-steroidal anti-inflammatory drugs; OR: Odds ratio; PRR: Pooled risk ratio; No drug-drug interaction; sustained relief; Supported by Meal independent dosing

Meta-analysis of 92 controlled trials of NSAIDs reported pooled dyspepsia percents and PRR by three dyspepsia definitions: strict, loose, and loose-less-heartburn.1

NSAIDs usage is associated with:

Increase in dyspepsia risk (p<0.05) by 36%.*1*Using the ‘strict’ definition, based solely on epigastric pain-related symptoms

Increase in development of GERD by ~4 times, OR=4.23.2

Heartburn development in 68% of patients and significant increase in acute reflux symptoms, p<0.0001, alone or in combination with aspirin.2

Related Articles

Login to continue

Meta-analysis of 92 controlled trials of NSAIDs reported pooled dyspepsia percents and PRR by three dyspepsia definitions: strict, loose, and loose-less-heartburn.¹

Increase in dyspepsia risk (p<0.05) by 36%.^1
Using the ‘strict’ definition, based solely on epigastric pain-related symptoms

Increase in development of GERD by ~4 times, OR=4.23.²

Heartburn development in 68% of patients and significant increase in acute reflux symptoms, p<0.0001, alone or in combination with aspirin.²