H2 tag- SEO Purpose
ACS: Acute coronary syndrome; AUROCC: Area under the receiver-operating characteristic curve; CI: Cumulative incidence; DAPT: Dual anti-platelet therapy; GIB: Gastrointestinal bleeding; HAS-BLED: Hypertension,No drug-drug interaction; sustained relief;
Supported by Meal independent dosing
Abnormal renal and liver function, Stroke, Bleeding tendency or predisposition, Labile International Normalized Ratios, Elderly, Drugs; PCI: Percutaneous coronary intervention; POEMA-10: Proton pump inhibitor, Obesity, Ethanol, Major
bleed before cardiac catheterization, PCI for ACS, and hemoglobin <10 g/dL before cardiac catheterization; RR: Risk ratio; SIGE: STEMI at PCI, having a labile INR at PCI, index GIB within 180 days of PCI, and previous precatheterization
Endoscopy within 6 months, VONOPrazan.
A single-center, retrospective study identified patients who had undergone cardiac catheterization with PCI followed by DAPT and reported specific models:1
Predicting GIB at 180 days: POEMA-10 score model1
Has a moderate accuracy with AUROCC=0.664.1
Observed GIB rate at the lowest and highest sextiles of predicted probability of GIB were 17.6% and 50.5%, respectively, with RR=2.88, p<0.001.1
PCI for ACS was the strongest predictor of GIB, p<0.001.1
Predicting recurrent GIB at 365 days1
SIGE score model
Has a scoring from 0 to 5.5 with AUROCC=0.773.1
Scores 0 and ≥4.5 indicate GIB rates of 10% and 100%, respectively.1
As SIGE score increases, CI of recurrent bleeding also increases.1
HAS-BLED score
Strongly associated with recurrent bleeding, p<0.009.1
Vono-Always on Duty
Vono, containing Vonoprazan molecule, is a Potassium Competitive Acid Blocker which helps in treatment of Refractory GERD, Erosive Esophagitis, H.Pylori, Gastric & Duodenal Ulcers
