Diagnostic efficacy and clinical applicability of the noninvasive pH-LHD nomogram in pulmonary hypertension due to left heart disease

According to a recent study, the pulmonary hypertension (pH) due to left heart disease (LHD) noninvasive nomogram demonstrates exceptional diagnostic value and clinical applicability, enabling a more precise assessment of the risk of pH in individuals with LHD. This study’s results were published in the journal, Heart & Lung.

In this study, a total of 361 patients with left heart disease (LHD) who had undergone right heart catheterization were enrolled. These patients were then randomly divided into two groups: a training cohort consisting of 253 patients (70%) and a validation cohort consisting of 108 patients (30%). The presence of pH was determined by a resting mean pulmonary arterial pressure (mPAP) of ≥25 mmHg, as measured through the right heart catheterization (RHC) examination. To analyze the data, the Lasso regression model was used for dimension reduction and feature selection. Subsequently, a nomogram was constructed based on multivariable logistic regression analysis.

175 individuals with left heart disease were diagnosed with pulmonary hypertension during their hospitalization, accounting for 48.5% of the sample cohort. Factors such as elevated New York Heart Association functional class, excessive resting heart rate, increased red blood cell distribution width, pulmonary artery systolic pressure, and right ventricular end-diastolic diameter assessed via echocardiography were independently linked to the prevalence of pH-LHD. The incorporation of these 5 variables in the nomogram demonstrated optimal calibration (Hosmer-Lemeshow test, P = 0.791) and strong discrimination (AUC = 0.866 [95% CI, 0.820-0.911]) for the validation set.

The above study demonstrated that the noninvasive nomogram for pH-LHD exhibits excellent diagnostic efficacy and clinical applicability, facilitating a more accurate evaluation of the pH risk in individuals with LHD.