Biomimetic Hydroxyapatite for Dentin Hypersensitivity

Introduction

	Dentin hypersensitivity (DH) causes sharp pain from stimuli like cold, heat, or pressure due to exposed dentinal tubules from enamel erosion or gum recession. It affects daily life, making eating and drinking uncomfortable.
	Hydroxyapatite (HAP), a biomimetic mineral, helps manage DH by blocking exposed tubules and reducing pain. This article reviews clinical trials on HAP's effectiveness in DH management.

Mechanism of Dentin Hypersensitivity

DH arises from fluid movement in exposed dentinal tubules, triggering nerve pain. Factors like enamel erosion and gum recession contribute to exposure. HAP treats DH by blocking tubules and promoting remineralization, making it effective in products like toothpaste and mouthwash.

Methods and Findings

The systematic review analysed 44 clinical trials, all involving human participants. Studies in languages other than English were translated and included. The trials compared HAP-based products to placebos, fluoride-based products, and other desensitizing agents. The meta-analysis revealed:

	HAP vs. Placebo: A significant 39.5% reduction in DH (95% CI [48.93; 30.06]).
	HAP vs. Fluoride: A 23% greater reduction in DH (95% CI [34.18; 11.82]).
	HAP vs. Other Agents: A 10.2% improvement (95% CI [21.76; -19.26]), though this was not statistically significant.

These results highlight HAP's superior efficacy compared to fluoride and placebos, with potential advantages over other desensitizing agents.

Clinical Implications

The findings suggest that regular use of HAP-containing products can reduce DH effectively which includes:

	Immediate Relief: Professional application of HAP offers rapid DH reduction, beneficial for post-procedure sensitivity.
	Long-Term Efficacy: Home use of HAP toothpaste consistently reduced DH over weeks to months.
	Safety: HAP is biocompatible and safe for daily use, with minimal side effects.

Enhancing HAP Efficiency

Research indicates that incorporating elements like zinc or magnesium into HAP formulations could enhance its desensitizing properties. Combining HAP with fluoride may further amplify its efficacy by promoting deeper remineralization.

Conclusion

HAP is an effective, non-invasive solution for DH, outperforming traditional fluoride treatments. By blocking tubules and aiding remineralization, HAP improves oral health and quality of life. Continued research will enhance its applications and benefits.

GGI-CO-A1-AQS-300032384-DVC-L24-0140
References:
Limeback H, Enax J, Meyer F. Clinical Evidence of Biomimetic Hydroxyapatite in Oral Care Products for Reducing Dentin Hypersensitivity: An Updated Systematic Review and Meta-Analysis. Biomimetics. 2023; 8(1):23. https://doi.org/10.3390/biomimetics8010023

Vantej Long Lasting Relief

Dental & Oral Health

Dentinal Hypersensitivity

Vantej Long Lasting Relief

Vantej, enriched with the Calcium Sodium Phosphosilicate (CSPS) molecule, is a highly effective occluding desensitizer. It provides relief from dentinal hypersensitivity caused by enamel damage due to attrition, abrasion, and erosion.

Know more

Biomimetic Hydroxyapatite for Dentin Hypersensitivity

Related Articles

Login to continue