Vitamin B12 supplementation improves frontal function in elderly patients with cognitive decline

According to a recent study conducted in middle aged and elderly patients with cognitive impairment, vitamin B12 supplementation can improve the effect of neuropsychological function. This study was published in the journal, Nutricion hospitalaria.

In this trial, a total of 115 patients with cognitive impairment were randomly assigned to vitamin B12 treatment group (n=58), with vitamin B12 500 mg/d administered intramuscularly for 7 days, and later by cobamamide 0.25 mg/d, and methylcobalamin 0.50 mg/d and the control group (n=57). Cognitive performance at baseline and after 6 months was assessed with the help of Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA).

It was found that patients who were given vitamin B12 supplementation showed significant improvement in attention, visual-constructional ability, and neuropsychological function compared to their matched group. This showed that vitamin B12 supplementation may improve frontal function in patients with cognitive decline.