Sediflù may be Effective for Pediatric Cough, suggests SEPEDIA Clinical Trial

This pilot randomized, double-blind, placebo-controlled, multicenter clinical trial evaluated the efficacy and tolerability of Sediflù, a herbal-based medical device, in treating persistent nocturnal and diurnal cough in children aged 3 to 7 days with either dry or productive cough. The study enrolled pediatric patients experiencing upper respiratory tract infections, assigning them to receive either Sediflù or a placebo.

The primary outcomes included the assessment of Sediflù’s soothing effects on dry and productive coughs both during the day and at night, alongside evaluating cough-related impacts on sleep quality for both the child and their parents, as well as cough frequency and severity.

Results demonstrated significant improvements in both nocturnal and diurnal cough scores in the Sediflù group starting from day 2, with marked reductions in daytime cough severity observed at days 3 and 7. Sediflù was well-tolerated, and its use was associated with notable enhancements in the quality of sleep for both children and their parents.

These findings suggest that Sediflù syrup may serve as an effective and well-tolerated treatment option for managing persistent coughs in young children with upper respiratory infections, potentially reducing cough duration and improving overall quality of life for affected families.