Safety and efficacy of either mirabegron, silodosin, or both in the expulsion of distal ureteric stones

A recent study demonstrated that lower ureteric stones can be effectively treated with both silodosin and mirabegron. Furthermore, when these medications are used together, they have been found to increase the rate of stone expulsion and reduce the duration of expulsion. This study’s findings were published in the journal, International Urology and Nephrology. 

This study included 105 patients, aged 20 to 56 years, who were diagnosed with a single radiopaque distal ureteral stone measuring ≤ 10 mm. The individuals were randomly allocated into three groups, each group containing 35 participants. Group A received an 8 mg daily dose of silodosin, group B was given 50 mg of mirabegron once daily, and group C received a combination of both medications. Treatment was given until the stone passed or for a maximum of four weeks. The stone-free rate was assessed by analyzing KUB films with or without ultrasonography.

Stone expulsion rate was higher in group C in comparison to groups A and B. The mean (standard deviation) time for expulsion of the stone in group A, group B, and group C was 14 ± 2.3 days, 11 ± 3.1 days, and 7 ± 2.2 days, respectively. Group C exhibited a significantly shorter stone expulsion time when compared to groups A and B. The incidence of renal colic in group C was significantly lower than that in groups A and B, leading to a decreased need for analgesics. Anejaculation was significantly more frequent in the silodosin group (73.9%) and combination group (84%) than in the mirabegron group.

Thus, it can be concluded that both silodosin and mirabegron are effective treatments for lower ureteric stones. Additionally, when these medications are utilized in combination, they have been shown to increase the rate of stone expulsion and decrease the duration of expulsion.