Conventional PPIs need 3–5 days to reach maximum acid secretion inhibition.1
Acid suppression with vonoprazan is much quicker and more profound than conventional PPIs, with effects starting from the first day of administration.2
VONOprazan offers the following advantages:1
It is rapidly absorbed and quickly accumulates in parietal cells.
It shows a pronounced effect after the first dose.
A single 20 mg dose can raise intragastric pH to nearly 7 within 4 hours.
A dose of 20 mg once daily maintains intragastric pH above 4 for 82.9% of 24 hours after 4 days and 85.2% after 7 days.
The pH remains above 4 without dipping below.
This rapid onset of action of VONOprazan is beneficial for managing breakthrough GERD symptoms and on-demand therapy.1
In the past month, have you prescribed VONOprazan for patients with moderate to severe GERD or erosive esophagitis who reported persistent NAB despite PPI treatment?
Vono 20-Always on Duty
Vono, containing Vonoprazan molecule, is a Potassium Competitive Acid Blocker which helps in treatment of Refractory GERD, Erosive Esophagitis, H.Pylori, Gastric & Duodenal Ulcers
