PEG vs. Lactulose: Enhancing Defecation Frequency With Fewer Side Effects

>40% of children with FC have <3 bowel movements per week.

PEG Improves Stool Frequency More Effectively Than Lactulose!

Better reduction of encopresis

More increase in weekly defecation frequency

~70% of children do not adhere to treatment, with ~40% of these cases due to adverse effects.

PEG causes fewer adverse effects than lactulose.

PEG is ~1.23x more effective than lactulose in achieving good clinical outcomes, offering a greater increase in defecation frequency and fewer side effects.

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Abbreviations ▼

ESPGHAN: European Society for Paediatric Gastroenterology Hepatology and Nutrition; FC: Functional constipation; NASPGHAN: North American Society for Pediatric Gastroenterology, Hepatology and Nutrition; PEG: Polyethylene glycol.

References ▼

1. Pashankar DS, Loening-Baucke V, Bishop WP. Safety of polyethylene glycol 3350 for the treatment of chronic constipation in children. Arch Pediatr Adolesc Med. 2003;157(7):661–4. 2. Afzal NA, Tighe MP, Thomson MA. Constipation in children. Ital J Pediatr. 2011;37:28. 3. Mansour HA, Ibrahim A, Mohamed A. Effectiveness of polyethylene glycol 3350 versus lactulose in management of functional constipation in children. Int J Pediatr Res. 2022;8:089. 4. Steiner SA, Torres MR, Penna FJ, et al. Chronic functional constipation in children: Adherence and factors associated with drug treatment. J Pediatr Gastroenterol Nutr. 2014;58(5):598–602. 5. Voskuijl W, de Lorijn F, Verwijs W, et al. PEG 3350 (Transipeg) versus lactulose in the treatment of childhood functional constipation: A double blind, randomised, controlled, multicentre trial. Gut. 2004;53(11):1590–1594.

LMRC Code: GGI-CO-A1-AQS-300024228-DCC-H24-0886

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PEG vs. Lactulose: Enhancing Defecation Frequency With Fewer Side Effects

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