Glycine and N-Acetylcysteine is effective as an anti-aging supplement in older adults
The findings of a recent study revealed that Glycine and N-Acetylcysteine (GlyNAC) supplementation in older adults improves age-associated abnormalities and promotes health in aging humans. The results of this study were published in the journal, The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences.
It was a randomized controlled trial, that included 24 Older adults (OA) and 12 young adults (YA). The OA subjects were randomized to receive either GlyNAC (n=12) or isogenous alanine placebo (n=12) for 16-weeks; and YA (n=12) received GlyNAC for 2 weeks. The participants were assessed before, after 2 and 16 weeks of supplementation to evaluate intracellular antioxidant glutathione (GSH) concentrations, oxidative stress (OxS), mitochondrial fatty-acid oxidation (MFO), molecular regulators of energy metabolism, inflammation, endothelial function, aging hallmarks, gait speed, muscle strength, body composition and blood pressure.
The results indicated that GlyNAC supplementation in OA has shown improvement in the aging factors including GSH deficiency, OxS, mitochondrial dysfunction, inflammation, endothelial dysfunction, IR, multiple aging hallmarks, impaired physical function, increased waist circumference, and systolic blood pressure.
Thus, GlyNAC supplementation in OA for 16-weeks was safe and well tolerated with benefits as an effective nutritional supplement against age-associated abnormalities and promotes health in aging humans.
