The efficacy and safety of a toothpaste containing bioactive glass-ceramic in treating dentinal hypersensitivity

According to a recent study, the bioactive glass-ceramic (HX-BGC) and NovaMin toothpaste exhibited more significant effects in addressing dentinal hypersensitivity when compared to the negative control group. No adverse reactions associated with the experimental toothpastes were noted. This study’s research findings were published in the Journal of Dentistry.

In this single-center, randomized, double-blind study, participants were randomly allocated to use one of the HX-BGC, NovaMin, or negative control toothpastes. Follow-up examinations were conducted immediately after a single use and at 2 weeks, 4 weeks , and 6 weeks. Schiff and Yeaple indices were used for intra-group and inter-group comparisons. The safety of the experimental toothpastes was evaluated through participant feedback and oral soft tissue examinations.

There was an increase in Yeaple indices across all groups, with significant differences noted between the HX-BGC group and the other two groups after a continuous 2-week period of use. Schiff indices decreased in all groups, with the NovaMin group demonstrating significant differences when compared to the negative control group. Significant improvement was observed in both the HX-BGC group and the NovaMin group by weeks 4 and 6 compared to the negative control group in both indices. The HX-BGC group exhibited better results in the Yeaple index compared to the NovaMin group. Additionally, no serious adverse reactions related to the toothpastes were reported or observed among the participants.

The above study confirmed the efficacy of HX-BGC in treating dentinal hypersensitivity and supported the clinical use of dentifrices formulated with HX-BGC. Both the HX-BGC and NovaMin toothpaste groups exhibited significantly greater efficacy in managing dentinal hypersensitivity compared to the negative control group. There were no adverse reactions reported in relation to the experimental toothpastes.