Xyzal

Where to Use How to Use What are the Side Effects Safety Advice Xyzal Dynamics

Xyzal: A Levocetirizine Dihydrochloride antihistamine for symptoms of Allergic Rhinitis and Urticaria

Xyzal is an antihistaminic medication. It is used to treat various allergic conditions such as allergic rhinitis or hay fever, conjunctivitis, some skin reactions such as eczema, Urticaria or hives, and reactions to bites and stings. It also relieves watery eyes, runny nose, sneezing, and itching.

How to Use?

Levocetirizine Dihydrochloride medicine must be taken as per the guidance of the physician.

Xyzal is available in the form of

Levocetirizine Dihydrochloride Tablets

Levocetirizine Dihydrochloride Syrup and

Levocetirizine Dihydrochloride Nasal Spray.

Nasal Spray: Insert the bottle tip into one nostril and close the other nostril. Direct the spray towards the sides of your nostril, away from the cartilage dividing the two sides of your nose. As you spray, breathe gently, and keep the head upright. Repeat the same process for the other nostril.

Tablet: Xyzal 5 mg Tablet can be taken with or without food. The dose required may vary depending on what indication it is taken for. This medicine is usually taken in the evening. It should be taken on days when there are symptoms, but if it is taken to prevent the symptoms, then it should be taken regularly. If a dose is missed or stopped earlier than advised, the symptoms may come back.

Syrup: Patients should take this medicine in the dose and duration as advised by their doctor. The label for 'directions before use' should be checked before use. Patients should Measure it with a measuring cup and take it by mouth. Shake well before use. Xyzal Syrup may be taken with or without food, but it is better to take it at a fixed time.

What are the Levocetrizine Side Effects?

Most side effects do not require any medical attention and disappear as the body adjusts to the medicine. If symptoms persist or bother, patients should consult their doctor

Common side effects of Xyzal include:

Fatigue

Headache

Dryness in mouth

Sleepiness

Xyzal (Levocetirizine)Safety Advice

Xyzal (Levocetirizine) Tablet may cause excessive drowsiness with alcohol

Warnings

Pregnancy

SAFE IF PRESCRIBED

Xyzal Tablet is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects on the developing baby. However, there are limited human studies.

Breastfeeding

SAFE IF PRESCRIBED

Xyzal Tablet is probably safe to use during breastfeeding. Limited human data suggest that the drug does not represent any significant risk to the baby.

Larger doses or prolonged use of Xyzal Tablet may cause drowsiness and other effects on the baby or a decrease in the milk supply.

Driving

UNSAFE

Xyzal Tablet may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney and liver disease

Xyzal Tablet should be used with caution in patients with kidney disease. Dose adjustment of Xyzal Tablet may be needed. It is not recommended in patients with severe kidney disease. Xyzal Tablet is safe to use in patients with liver disease. No dose adjustment of Xyzal Tablet is recommended.

Xyzal Syrup

Xyzal Syrup should be used with caution in patients with kidney disease.

Dose adjustment of Xyzal Syrup may be needed.

Xyzal Syrup is safe to use in patients with liver disease. No dose adjustment of Xyzal Syrup is recommended. However, dose adjustments may be required in severe liver disease.

Xyzal Dynamics

Mechanism of Action

The active component of Xyzal, Levocetirizine dihydrochloride, is the R-enantiomer of cetirizine hydrochloride, a racemic compound with antihistaminic properties. It is an orally active and selective H1-receptor antagonist. Histamines act on H1 receptors, causing the symptoms commonly seen in allergic reactions. Xyzal inhibits these H1 receptors.

General Information

Xyzal is specifically indicated for the relief of symptoms associated with allergic rhinitis (seasonal and perennial) in adults and children of 6 years of age and older. Xyzal is also indicated for the treatment of the uncomplicated skin manifestations of chronic idiopathic urticaria in adults and children of or above six years of age.

Abridged Prescribing Information

XYZAL® Tablets and Oral Solution (Levocetirizine Dihydrochloride)

Name of the Medical Product: 1) Xyzal (Levocetirizine dihydrochloride) 5 mg film-coated tablets. 2) Xyzal (levocetirizine dihydrochloride) 5mg/10ml oral solution. Qualitative And Quantitative Composition: 1) Each film-coated tablet contains 5 mg Levocetirizine dihydrochloride. 2) 1ml of oral solution contains 0.5 mg levocetirizine dihydrochloride. Pharmaceutical Form: Film-coated tablet: White to off-white, oval, film-coated tablet with a Y logo on one side. Oral solution: clear and colourless liquid. Therapeutic indications: For the treatment of Allergic Rhinitis and Chronic Urticaria in children from 6 months of age. Posology and method of administration Children 6 months to 5 years of age: 1.25mg once daily. Children 6 to 11 years of age: 2.5 mg once daily. Adults and children 12 years and older: 5 mg once daily. Contraindications: 1) Hypersensitivity to levocetirizine or any of the other constituents of the formulation, to hydroxyzine or to any piperazine derivatives. 2) Patients with severe renal impairment at less than 10 ml/min creatinine clearance. Special Warnings and Special Precautions for Use: Precaution is recommended with intake of alcohol. Methyl parahydroxybenzoate and propyl parahydroxybenzoate included in the oral solution may cause allergic reactions (possibly delayed). The use of the film-coated tablet formulation is not recommended in children aged less than 6 years since this formulation does not allow for appropriate dose adaptation. It is recommended to use a paediatric for formulation of Levocetirizine. Undesirable Effects: Headache, Somnolence, Mouth dry, fatigue, palpitations, tachycardia, nausea, vomiting, diarrhoea and vomiting. Overdose: Symptoms of overdose may include drowsiness in adults and initially agitation and restlessness, followed by drowsiness in children. Keep out of reach of children.

Please refer to full prescribing information before usage. Available on request from Dr. Reddy's. For further information please write to Dr. Reddy's Laboratories Ltd., 8-2-337, Banjara Hills, Hyderabad- 500 034. India

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