The main difference between Protectis, Gastrus, Prodentis and Osfortis is that they contain different probiotic L. reuteri strains, or combinations of L. reuteri probiotic strains. • Protectis contains L. reuteri DSM 17938 • Osfortis contains L. reuteri ATCC PTA 6475 • Gastrus contains L. reuteri DSM 17938 and L. reuteri ATCC PTA 6475 • Prodentis contains L. reuteri DSM 17938 and L. reuteri ATCC PTA 5289 All BioGaia’s probiotic products have been tested in clinical studies and found safe and effective. All BioGaia’s probiotic L. reuteri strains have been shown to survive in the human gastrointestinal tract and to temporarily colonise the small intestine. They have also been shown to have a positive effect on the microbiota composition.

Since every gastrointestinal tract is unique, some individuals might experience a temporary change in gut motility. BioGaia probiotics very rarely cause side effects in the amounts recommended for the products. Some individuals might experience gas (flatulence), but that generally disappears after a few days. No serious adverse effects have been observed in clinical trials up to the maximum tested dosage of 10 billion CFU per day.

BioGaia products come in different versions, we therefore recommend following the instructions given on the package. However, if room temperature is above 25°C/77°F, we always recommend storage in the fridge.

BioGaia Protectis Drops should not be stored in the freezer as this will significantly shorten the shelf-life of the product.

BioGaia Protectis Drops comes in two different versions, we therefore recommend you to follow the instructions on the package. However, if room temperature is above 25°C/77°F, we always recommend storage in the fridge.

In BioGaia we are constantly working on improving our products. The Easydropper is a new delivery system for probiotic products. It has an improved drop function which facilitates the administration of the product, and less environmental impact compared to glass bottles.

The spots are not dangerous, and the product can still be used. BioGaia Protectis tablets contain ascorbic acid, which is an antioxidant that contributes to the stability of the tablets. Over time, the ascorbic acid oxidizes and the color becomes darker. This darkening is seen as small “spots” on the tablet.

Multi-strain products containing several strains in high doses do not necessarily have a better effect than a single-strain product. Important criteria when choosing a probiotic product are: • The probiotic bacteria must be defined on strain level • The probiotic product must have been tested in human clinical studies, with the same dose and with the same bacterial strain(s) as in the commercial product.

Limosilactobacillus reuteri (L. reuteri) (formerly known as Lactobacillus reuteri) is a probiotic bacterium that has co-evolved with humans since the beginning of time, and because of that it has adapted to its host. L. reuteri is one of the first bacterial species to naturally become established in the microbiota of the new-born. BioGaia’s probiotic products with L. reuteri are among the most scientifically well-documented probiotics in the world in terms of both - efficacy and safety. To date, over 220 clinical studies with BioGaia’s L. reuteri-strains have been performed in approximately 19,000 people of all ages. Positive results have been shown for several gastrointestinal disorders, oral health, and bone health.