Fondaparinux, a synthetic anticoagulant, consists of a highly sulfated penta saccharide derived from the minimal antithrombin (AT)-binding region of heparin. It works as an indirect factor Xa inhibitor by binding to AT and producing a conformational change in AT that improves AT's ability to inactivate factor Xa

Ref: World J Cardiol 2022 January 26; 14(1): 40-53

Fondaparinux can be administered through subcutaneous (s.c.) or intravenous (i.v.) routes. The bioavailability is 100% after s.c. administration of fondaparinux in healthy volunteers and mean maximum plasma concentration is achieved at 1.7 h. The mean maximum plasma concentration with i.v. dose is achieved at an even faster rate without affecting half-life. When compared to LMWHs like Enoxaparin and UFHs, fondaparinux sodium had no effect on fibrinolytic activity or bleeding time at the prescribed dose, promoting hemostasis and a favorable bleeding risk profile. Fondaparinux does not bind to or interact with other plasma proteins or cellular elements such as platelets or platelet factor 4, and thus, unlike Enoxaparin and UFH, it does not cause heparin-induced thrombocytopenia-like syndrome.

Ref: World J Cardiol 2022 January 26; 14(1): 40-53

Fondaparinux does not require monitoring in routine clinical use. The anticoagulant effect of fondaparinux can be assessed with dedicated anti-Xa assays in high-risk patient populations (renal insufficiency, bodyweight less than 50 kg). Fondaparinux is mainly cleared through the kidney and is excreted unchanged in the urine. Clearance of this drug is reduced in individuals with reduced creatinine clearance and is therefore not recommended for use in individuals with creatinine clearance < 30 mL/min.

Ref: World J Cardiol 2022 January 26; 14(1): 40-53

Fondared 2.5

Prophylaxis of venous thromboembolic events (VTE) Management of unstable angina or non-ST segment elevation myocardial infarction (UA/NSTEMI) for the prevention of death and subsequent myocardial infarction.

Management of ST segment elevation myocardial infarction (STEMI) for the prevention of death and myocardial reinfarction in patients who are managed with thrombolytics or who initially are to receive no form of reperfusion therapy.

Fondared 7.5

Treatment of Acute Deep Vein Thrombosis (DVT) and treatment of Acute Pulmonary Embolism (PE)