Adults: The usual dose of oral Doxycycline is 200 mg on the first day of treatment (administered 100 mg every 12 hours) followed by a maintenance dose of 100 mg/day. In the management of more severe infections (particularly chronic infections of the urinary tract), 100 mg every 12 hours is recommended. (2.1)

For children above eight years of age: The recommended dosage schedule for children weighing 100 pounds or less is 2 mg/lb of body weight divided into two doses on the first day of treatment, followed by 1 mg/lb of body weight given as a single daily dose or divided into two doses on subsequent days. For more severe infections up to 2 mg/lb of body weight may be used. For children over 100 lbs, the usual adult dose should be used. (2.2)

Dose: 200 mg IV on Day 1, then 100 mg to 200 mg IV per day, with the 200 mg dose administered as 1 or 2 infusions

Duration: Every 12 hours

Dilution: The content of the vial should be reconstituted with 10 ml (for the 100 mg/vial container) of sterile water for injection

Administration: Slow IV infusion over a period of 1-4 hours

Therapy Continuation: Continue for at least 24-48 hours after symptoms and fever have subsided

Caution: Rapid administration should be avoided if intravenous therapy is given over prolonged periods, it may result in Thrombophlebitis

Adverse reactions observed in patients receiving tetracyclines include anorexia, nausea, vomiting, diarrhea, rash, photosensitivity, urticaria, and Hemolytic Anemia.

Contraindications

Doxycycline is contraindicated in persons who have shown hypersensitivity to any of tetracyclines.

Use in Special Population

Pregnancy: Doxycycline injection is contraindicated in pregnancy. Animal studies have shown that Doxycycline injection can cause Embryotoxicity. It is considered as pregnancy category D drug.

Children: Doxycycline injection is not recommended for children below 8 years. Administration of Doxycycline injection may decrease fibula growth rate in premature babies.

Nursing Mothers: Tetracyclines are secreted in breast milk, but the extent of absorption by the infant is unknown. Short-term is not contraindicated and effects of long-term are unknown.

Composition: Each capsule contains Doxycycline 100mg + Lactic acid bacillus spores-5 billion. Therapeutic Indications: For adult patients prone to intra-abdominal bacterial infection & antibiotic associated diarrhoea. Dosage and Administration: In Adults for the treatment of acute infections is two capsules per day (as a single dose or in divided doses) followed by a maintenance dose of one capsule/day. In the management of more severe infections, two capsules daily should be given throughout treatment. Contraindications: Doxycycline is contraindicated when hypersensitivity to any of the Tetracycline's. Drug interactions: Anticoagulant, co-administration of Tetracyclines with peniciIIin, Antacid, OC pills, Antiepileptic’s etc. Warnings & Precautions: During tooth development (last half of pregnancy, infancy and childhood to the age of 8 years) may cause permanent discoloration of the teeth (yellow-gray-brown). Evaluate for Clostridium difficile-associated diarrhoea. Limit sun exposure. Overgrowth of non-susceptible organisms, including fungi & superinfection. Dosage adjustment required in patients with hepatic impairment. Adverse reactions: In patients receiving tetracyclines include anorexia, nausea, vomiting, diarrhoea, rash, photosensitivity, urticaria, and hemolytic anemia. Special population: Can be prescribed in the elderly in the usual dosages. Not recommended for use in paediatric population due to complexity of dose calculations with a combined dosage form. Pregnancy Category D. Tetracyclines are excreted in human milk; Doxycycline use during nursing should be avoided if possible. Further information available upon request.

Composition: Combi-pack contains (A) Vial of Doxycyline for injection USP 100mg (B) Ampoule of Sterile water for Injection IP 10ml.

Therapeutic Indications: Broad spectrum antibiotic for infection by Rickettsia, sexually transmitted disease, Respiratory tract infection, specific bacterial infections etc. Dosage and Administration: In Adults usual dosage is 200 mg on first day in one or two infusions, subsequently as per disease severity 100/200 mg daily. In Syphilis dosage can be 300 mg daily for 10 days. Infusion should be for 1-4 hours. In Paediatric patients weighing >45kg adult dose can be used. In paediatric patients weighing < 45kg and greater than 8 years of age dose of 2.2mg/kg of body weight can be administered every 12 hours. Contraindications: Doxycycline is contraindicated when hypersensitivity to any of the Tetracycline’s. Drug interactions: Anticoagulant, co-administration of Tetracyclines with penicillin, Antacid, OC pills, Antiepileptic’s etc. Warnings & Precautions: during tooth development (last half of pregnancy, infancy and childhood to the age of8 years) may cause permanent discoloration of the teeth (yellow-gray-brown). Evaluate for Clostridium difficile- associated diarrhoea. Limit sun exposure. Overgrowth of non-susceptible organisms, including fungi & superinfection. Adverse reactions: In patients receiving tetracyclines include anorexia, nausea, vomiting, diarrhoea, rash, photosensitivity, urticaria, and hemolyticanemia. Special population: Pregnancy Category D. Tetracyclines are excreted in human milk; Doxycycline use during nursing should be avoided if possible. Further information available upon request.